Background: Several litres of intravenous fluid (usually 50 to 75 mL/kg) are given in the first several hours of therapy, defining a "liberal" fluids strategy to septic shock care. In septic shock, capillary endothelial dysfunction causes fluid to leak out of the blood vessels, leading to hypovolemia and decreased vasomotor tone. Aim: assess the efficacy of restrictive vs liberal intravenous fluid delivery in patients with severe sepsis and septic shock. Patients and Methods: Patients hospitalised to the intensive care unit (ICU) for more than 48 hours were the focus of this randomised control experiment, in which data was gathered on 50 patients in a row before the intervention and 50 patients in a row after it. The study was done in the Saudi German hospital in Cairo. Results: Length of time on organ support, time in the intensive care unit, time in the hospital, and change in bicarbonate (in millimoles per litre), all differed significantly between the two groups. In terms of demographics, there were no discernible differences among the two groups, associated comorbidities and Body mass index or Weight. Conclusion: Restrictive Group has better outcome than Liberal Group regarding to comparison Between Restrictive Versus Liberal Intravenous Fluid Administration in Severe Sepsis and Septic Shock.

Versus Liberal Intravenous Fluid, Sepsis, Septic Shock