Cancer is a well-known public health problem, and it is a major cause of death worldwide. Colorectal Cancer (CRC), is the most common malignant cancer in the gastrointestinal tract and Carcinoembryonic antigen (CEA) is the most common diagnostic biomarker used in (CRC) and most of the gastric tumors which is used to identify/monitor or detect the type of tumoras it’s used as a predictive and prognostic biomarker.High mobility group box protein-1 (HMGB1) proteins are one of the majorReceptors for Advanced Glycation End Products(RAGE)-ligands that contribute to inflammation consequences and an increased release of RAGE ligands, can play multiple roles in promoting the pathogenesis of (CRC), as it had been heavily implicated in the pathogenesis of (CRC).The research aims to detectthe possible relationship between CEA and HMGB1 in (CRC).

Cancer, CRC, CEA, HMGB1