The estimated 55 million people worldwide are thought to be afflicted with Alzheimer's disease (AD), and the number of new instances of the disease is rising at a rate of 10 million each year, making the situation extremely concerning for the entire world. Given that there is now no cure for neurodegenerative diseases like AD, this serves as an important reminder to improve research and treatment. The blood–brain barrier, which prevents blood–brain drug molecules from entering the brain compartment, is mostly to blame for the brain's intricate structure and the dearth of medications for treating neurodegenerative disorders. For the purpose of delivering medication molecules to the intended location in the brain, a number of innovative and traditional formulation techniques, including oral, intravenous, gene. Iontophoresis is a non-invasive technique that uses an electric field to deliver drugs locally and systemically. Diffusion of the chosen medication via the skin, mucosa, enamel, dentin, and other tissues is made possible by iontophoresis. Therapeutic compounds can be supplied 10–2000 times more efficiently than traditional methods.

Iontophoresis, transdermal, Alzheimer’s disease, blood-brain barrier, neurodegenerative disorder