The present study was carried out to develop the Bilayer tablets of Phenylephrine as sustained release and Loratidine as immediate release component. Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Loratadine is a second-generation peripheral histamine H1- receptor blocker used to treat allergies. In the present study the the bilayer tablets of Phenylephrine(SR) and Loratidine(IR) was formulated and evaluated, percentage friability for all the formulations was below1% indicating that the friability was within the range of standard specification. All the formulations showed post-compression parameters i.e friability and drug content were within acceptable official IP limits.Various sustained release formulations were formulated with super disintegrants, polymer alone; and microcrystalline cellulose was used as diluents. The tablets were evaluated for pharmacopoeial and non-pharmacopoeial (industry specified) tests. Based on the results, F-8, F-4 were identified as better formulation amongst all formulations

Loratidine, Phenylephrine, Bilayer tablets.