Volume 20 No 12 (2022)
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DEVELOPMENT AND EVALUATION OF ANTI-INFLAMMATORY GEL CONTAINING ZINGER OFFICINALE
SVVNSM Lakshmi ,Suryam Gugulothu ,Chandan Mohanty ,S.R.Senthilkumar ,T Venkatachalam ,Chandan Nayak P.V. Murali Krishna
Abstract
A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid. Gels and jellies are composed of small solids dispersed in a relatively large amount of liquid, yet they possessa more solid-like than liquid-like character. The characteristic of gel and jelly is the presence of some cutaneous structure, which provides solid-like properties.The gel consists of a natural or synthetic polymer forming a three-dimensional matrix throughout a dispersion medium or hydrophilic liquid. After application, the liquid evaporates, leaving the drug entrapped in a thin film of the gel-forming matrix physically covering the skin. Gel formulations prepared with Carbopol 934 and Carbopol 940 showed good homogeneity, no skin irritation, stability, and antiinflammatory activity. Formulation F2 with 5% extract and 4% Carbopol 940 showed the best formulation with significant anti-inflammatory activity
Keywords
Ginger gel ,carbopol ,anti-inflammatory Activity ,gel formulations
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