Volume 20 No 22 (2022)
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Dendrimer A Polymeric Molecules For Enhance Drug Delivery With Reduce Cytotoxicity For Treatment Of Leishmaniasis
Pradeep Kumar, Prof. (Dr.) Gajendra Kumar Aseri, Dr. Neelam Jain , Dr. Vishal Saxena , Pradeep Kumar
Dendrimers are synthetic nanosized, symmetrical molecules with unique architectural properties in which a group of atoms is surrounded by the symmetric branches known as Dendron’s, these unique properties are responsible for their various applications in medical field and support as ideal nano-carrier molecule for drug delivery with several aspects such as target specific delivery, solubility enhancement and bioavailability of drug molecules. Dendrimers have attracted attention as drug delivery system for the treatment of infectious diseases such as leishmaniasis. Leishmaniasis is a vector born disease caused by a species of genus leishmania and spread by vector of genus phlebotomus. Several medical remedies are used as a treatment for elimination of leishmaniasis but various negative outcomes associated with these remedies such as adverse side effect, cost effectiveness and resistance, which makes them so far from the reach of patients, belongs to the poorest areas of the world. The aim of this study is to discuss the potential of dendrimer formulations with several drugs in treatment of leishmaniasis diseases.
mphotericin B PAMAM dendrimer, PPI dendrimer, Drug Delivery System, leishmaniasis, DrugDendrimer Conjugate
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