


Volume 20 No 22 (2022)
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Design, Synthesis and Antibacterial Evaluation of some new 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives
Prerana B. Jadhav, Sunayana R. Vikhe , Pooja S. Jadhav , SonaliN. Valate , SonaliS. Jadhav
Abstract
Compounds containing 1,3,4-Oxadiazole nucleus investigated for CYP51 inhibitory activity. Current research
work describes the designing, molecular docking, synthesis and structural elucidation of certain new 2,5-
disubstituted 1,3,4-Oxadiazole derivatives investigated for antimicrobial activity. Series of the 2,5-disubstituted
1,3,4-Oxadiazole derivatives were designed and show good in silico ADME properties. The molecular docking
study was done by Autodockvina software exploring better interaction with target protein and could be the
potent inhibitor of ergosterol biosynthesis. The novel 2,5-disubstituted 1,3,4-Oxadiazole derivatives
synthesized by conventional heating method as well as microwave irradiation method. The microwave assisted
synthesis remarkely higher yield at less time compared to conventional synthesis. Structural elucidation was
done by FTIR, 1H NMR and Mass spectroscopy. The synthesized compounds subjected to in vitro antimicrobial
activity by agar diffusion method and all compounds show good inhibition of bacterial growth.
Keywords
In silicoADME, Molecular Docking, Synthesis, 1,3,4- Oxadiazole, Antimicrobial Activity
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