The balance in the production of interleukins has an important role in regulating the immune response in infections caused by Candida albicans, Therefore, this study focused on determining the level of some interleukins, (interleukin-6 and interleukin-10) as an immune response against Candida using rats as a model. Rats were inoculated vaginally with Candida albicans to obtain infection and the level of interleukin was measured at different periods (2,4,6,8) days after rats immunized with Candida albicans using ELISA techinque. four types were isolated of Candida genus in current study, C. albicans (71.43. %), C. glabrata (14.29), C. parapsilosis (8.57%) and C. tropicalis (5.71%) and the concentration of IL-6. The concentration of interleukin 6 increased at the second day after the immunization of rats with C.albicans, and its highest concentration was recorded on the sixth day (162.880 pg/ ml) after rats inoculated with C. albicans, while the interleukin 10 increased also on the second day after the inoculated, and its highest concentration (123.3456 pg/ml) was recorded on the eighth day. Generally, coordination between interleukin 6 and 10 is essential in the immune response to vaginal candidiasis.

Vaginal Candidiasis, Il-6, IL-10, ELISA