Over the previous decades, the production of controlled drug delivery has become important in the pharmaceutical era. The pharmacological action depends on the concentration of drug administered at the action site in body which depends on the dosage forms and the rate extent of absorption of the drug at the site of action. Physiochemical parameters such determination of solubility, melting point, partition coefficient, drug-excipient interaction, λmax scan using UV-spectrophotometry, FT-IR spectrophotometry were performed in this study. The regression coefficient (R2) was 0.999 which was shows the linearity of curve. The line of equation for the standard curve was y = 0.041x + 0.001. The drug excipient interaction study was performed to check in interaction between drug and other formulation excipients by spectrophotometrically. There was no interaction was found between drug and excipients and it was clearly seen and confirmed by UV spectrophotometrically scan graph of drug solution and mixture of drug and excipients in fig 6.3 and 6.4. There was no fluctuation in wavelength of mupirocin calcium.Pre-formulation of drug and excipient was performed in which physiochemical properties and other parameters of drug were studied. Physiochemical parameters such determination of solubility, melting point, partition coefficient, drug-excipient interaction, λmax scan using UV-spectrophotometry, FT-IR spectrophotometry were performed in this study.

Pharmacology. Administered, Absorption, Controlled drug, interaction