Development And Evaluation of In-Situ Floating Gel in Treatment of Gastroesophageal Reflux Disease (Gerd)

Volume 19 No 11 (2021)

Vikram Tanaji Deshmukh, Dr. Jagdish Chandra Pati

DOI: 10.14704/nq.2021.19.11.NQ21238

Abstract

Gastroretentive drug delivery systems can deliver narrow-window drugs to the upper stomach at a controlled rate. The raft forming process is better than floating structures, liquid dosing mediums, and in situ gelation for sustained drug release in the upper GI tract. According to statistics, lafutidine is exactly put in the parietal cells of the stomach mucosa, where the upper gastro-intestinal tract absorbs it. Lafutidine capsules had 65–70% bioavailability compared to intravenous infusion. Stability and absorption are acceptable between 1 and 4. The colon and lower gastrointestinal tract degenerate

Keywords

In-Situ Floating Gel, Gastroesophageal Reflux Disease (GERD), Lafutidine

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