Volume 20 No 10 (2022)
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Dihydropyrimidine-2(1-h)-one derivatives with carbazole moiety: An approach to evaluate the Antioxidant Activity
Purushotham K.N , T YunusPasha, B. Ramesh
Abstract
This study was designed to evaluate antioxidant activity of all the synthetic compounds which are synthesized in laboratory of department of pharmaceutical chemistry, Adichunchanagiri College of pharmacy containing carbazole moiety. Among all the characterized compounds DPO-08 (4-(9Hcarbazol-9-yl)-6-(4-dimethylaminophenyl)-5,6-dihydropyrimidin-2(1H)-one) compound shows the better dose dependent antioxidant activity in DPPH method. The compound DPO-08 was characterized by the melting points-234–236°C; Mass interpretation data (m/z): 382.45, 166.06; IR interpretation (KBr) νmax, cm−1: 3420 (NH Str), 1455 (Ar-C=C), 1238(C-N), 3051 (Ar C-H) and proton NMR interpretation(DMSOd6, 400 MHz-δ): (15H, Ar-H) 8.105-7.119, (1H, N-H) 11.236, (H6, N- (CH3)2)3.491-2.894. It was found that in this case the introduction of dimethylamino functional group to the para/4th position phenyl group to the Dihydropyrimidine-2(1H)-one derivatives with carbazole nucleus, supplemented with increasing of antioxidant activity in DPPH method
Keywords
carbazole, antioxidant activity, in-vitro method, DPPH Method, dihydropyrimidinones
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