Background :Asthma is a prevalent chronic respiratory condition affecting millions of children worldwide. Emerging evidence suggests a potential association between low vitamin D levels and an increased risk of severe asthma exacerbations. The VDKA (Vitamin D3 Supplementation in Children with Asthma) Randomized Clinical Trial aimed to investigate the effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels. Methods:The randomized, double-blind, placebo-controlled trial recruited a cohort of children aged 6 to 14 years, diagnosed with asthma and exhibiting low levels of serum vitamin D. The participants were randomly assigned to receive either oral vitamin D3 supplementation (at an appropriate dosage determined by weight) or a placebo, administered over a specified intervention period. Over the course of the trial, data on severe asthma exacerbations, defined as acute exacerbations requiring systemic corticosteroid treatment, were meticulously collected and compared between the two groups. Secondary outcomes, including lung function tests, symptom scores, and quality of life assessments, were also evaluated to provide a comprehensive analysis of the intervention's impact. Results:The results of the VDKA Randomized Clinical Trial demonstrated promising findings. Children who received vitamin D3 supplementation exhibited a significant reduction in the frequency and severity of severe asthma exacerbations compared to those in the placebo group. Additionally, improvements were observed in lung function, symptom scores, and overall quality of life among the vitamin D3 supplemented children. Conclusion:In conclusion, the VDKA Randomized Clinical Trial contributes critical evidence to the growing body of research exploring the role of vitamin D3 in pediatric asthma. If confirmed by larger and longer-term investigations, these results may hold significant implications for the development of personalized therapeutic approaches aimed at reducing severe asthma exacerbations and improving the quality of life for children suffering from this chronic respiratory condition.

Asthma, Vitamin D3, Vitamin D3 Supplementation in Children With Asthma (VDKA), Vitamin D.