ENHANCED SUSTAINED RELEASE CHARACTERISTICS OF PROPRANOLOL HYDROCHLORIDE IN FORMULATION SR008 WITH HPMC K100M

Volume 20 No 8 (2022)

Mandeep Malhi, Satish Kumar Sharma, ,Hanumanthrao C Patil

DOI: Drug, Propranolol, Cardiovascular, Polymers, Patient.

Abstract

Propranolol hydrochloride, microcrystalline cellulose (PH-101), Microcrystalline Cellulose (PH-102), HPMC (K15 M), HPMC (K100 M), HPMC (K4 M), HPC LF, Isopropyl alcohol, Povidone (K-30),Magnesium Stearate were used in the different formulations. Among different formulations, SR008 having HPMC K100M was showing better sustained release characteristics, 69.1%, 76.6%, 82.3% for 8, 10, 12 hr. respectively compared to other formulations with 71% moisture content and 71N hardness.

Keywords

Drug, Propranolol, Cardiovascular, Polymers, Patient.

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