Introduction: Psoriasis is a chronic, immune mediated inflammatory disease, affecting approximately 1–3 % of the world’s overall population. The ocular manifestations of psoriasis are often neglected as skin and joint involvement are major causes of concern. Dry eye disease is an inflammatory disease that has many features in common with autoimmune disease. Aim and objectives: To compare the severity of dry eye in patient with psoriasis and those without psoriasis. Materials and Method: This was a 1 year hospital based case-controlled study done on 60 consenting patients clinically diagnosed to have psoriasis by the dermatologist: who were referred to our department and 60 patients without psoriasis or other co-morbidities. Evaluation for dry eye was done using Ocular Surface Disease Index (OSDI) questionnaire, Schirmer’s I Test and Tear Film Break - Up Time and recorded. Statistical analysis was done by R i386 3.6.0 statistical software and Excel. Results: A total of 60 psoriasis patients and 60 normal individuals were studied, male to female ratio was 2:1 in both the groups. The mean duration of psoriasis in our study was 9.43±8.69 years. Chronic plaque type of psoriasis was the most common type of psoriasis observed amongst the patients (81.67%).70% (42/ 60) patients had dry eye manifestations. Dry eye was common in patients with PASI score > 10. There was no statistical significance between duration of disease and presence of dry eye in psoriasis. Conclusion: Psoriatic patients have higher chances of tear film dysfunction and dry eye syndrome emphasising the need of periodic ophthalmological evaluation in them

Dry eye, Psoriasis, OSDI, PASI