Aiming to provide a better understanding of the interconnection between telomere length and Alzheimer’s Disease, this paper also tries to consider the role of certain biomarkers in mediating this relation. Chromosomes are structures that contain DNA and hence, other genetic materials; every chromosome has a protective cap known as telomeres that reduce the risk of misread DNA during replication, and these telomeres constantly and relatively shortening with each subsequent cell division especially with increasing age and stress. Shortened telomeres have been linked to different age-related Diseases and conditions including; Alzheimer’s Disease- a Disease that is neurodegenerative in nature and is characterized by slowness in the overall cognitive function as well as memory. The present synthesis provides current literature about the telomere biology, more specifically, telomere shortening and its potential role in the development and course of Alzheimer’s Disease. We pinpoint biomarkers which may account for the associations described above, including inflammatory indexes, measures of OS, and polymorphisms. These biomarkers have not only contributed to the elucidation of the Alzheimer’s mechanism but also provided early markers and also therapeutic targets. As well as assessing biomarkers (telomere length, neuroplasticity potential, cognitive reserve) this paper discusses potential factors influencing biomarkers and their implications on the development and progress of Alzheimer’s Disease. Some of the causes include; The use of certain foods and drinks, age, level of physical activity, stress, exposure to certain chemicals among others. For instance, dietary intake of antioxidant and vigorous exercise have been found to lessen the extent of telomere shorting, whereas cluttered stress and unhealthy living patterns have been linked to heightened progression towards shortening of telomeres. This also seeks to synthesise information from various studies examine this interaction by encompassing results from cross-sectional and longitudinal, multinational, interventional and observational studies to amalgamate knowledge on the complex relationship between telomere length, Alzheimer’s Disease and its determinants. This integrative strategy not only refines our understanding of the underlying pathophysiological processes but also creates opportunities for the creation of individualized methods for the prevention and management of Alzheimer’s Disease.

Telomere Length, Alzheimer’s Disease, Biomarkers, Aging Diet, Lifestyle Factors, Neurodegeneration, Cellular Aging, Genetic Predispositions, Environmental Influences.