Millions of diabetics use herbal medicine for economic and cultural reasons. The present study investigates the antidiabetic and antioxidant potential of the aqueous solution of fenugreek (Trigonellafoenum-graecum) at a dose of 50, 100 mg/kg in alloxan -induced diabetic model. Forty adult male rats, 14 weeks old, weighting 200-250g were divided into four groups (ten for each group). The first group was as a control group received distal water, the second group was injected with alloxan 120 /kg/b.w and nicotinamide 50 mg/kg/B.W positive group without treatment. The third diabetic group received treatment with 50 mg/kg/b.w. of fenugreek while, the fourth diabetic group received treatment with 100 mg/kg/B.W. of fenugreek. After rats received oral fenugreek daily, for 30 day, showed that (OGTT) was significantly reduced following fenugreek treatment while, high-density lipoprotein (HDL) increased after daily .Cholesterol, triglycerides, LDL and VLDL decreased significantly in all groups. In conclusion, the current study showed some potential benefits of fenugreek use.

diabetes, alloxan, fenugreek, OGTT, lipid profile