Type 2 diabetes mellitus (T2DM) accounts more than 80 % of all diabetic cases. It may present with microvascular and macrovascular complications.The term intermittent fasting has been used to describe various types of caloric restriction for several hours per a day, alternating days or several days. Methods and materials: Rats were randomly classified into control group, diabetic group (D) and Diabetes + Intermittent fasting group (D + F) group. Diabetes was induced by receiving high-fat diet (HFD) for 2 weeksfollowed by intraperitonealinjection of streptozotocin. The rat whose blood glucose was ≥ 200 mg/dl was considered diabetic. 3 days from streptozotocin injection, each rat was deprived from food only for 16 h daily for 28 days (nothing but water). Serum glucose, insulin, oxidative injury markers (MDA and TAC) were measured. Result: In D group, it showed significantly elevated serum levels of glucose and MDA and significantly decreased serum levels of insulin and TAC in comparison with control group. While, in D + F group showed significantly decreased serum levels of glucose and MDA and significantly elevated serum levels of insulin and TAC in comparison with D group.

Male Albino Rats, Diabetic Changes, Water Adlibitum.