Background: Nutrition interventions are recommended for most cancer patients. Chronic caloric restriction has powerful anticarcinogenic actions, also, fasting has demonstrated reductions in chemotherapy related side effects and improved treatment tolerability and effectiveness, evidence suggests that fasting or prolonged fasting is safe and may have a protective effect on healthy cells from chemotherapy toxicity, also decreasing tumor growth. Fasting and exercise is recommended because lead to improve cancer related outcomes, the studies showed that intermittent fasting between 24 and 72 hours can be safe and feasible as determined by treatment side effects, it has become in growing interest in both the scientific and lay community as an alternative to caloric restriction. Materials: According to a survey by the international food information council foundation, intermittent fasting has become the most popular diet in the last year, and patients with cancer are seeking about its beneficial effects for cancer prevention and treatment. However, we needs additional trials are needed to elucidate the risks and benefits of fasting for patients with cancer. Results: the findings suggest that the combined fasting and exercise is improve the health and helps on the preventing from tumor. Intermittent fasting may be usefule in adults with cancer through means of weight manaement. The health benefits of caloric restriction result from a passive reduction in the production of damaging oxygen free radicals. In this review, we provide evidences of fasting as intervention in the cancer and discuss the potential benefits and mechanisms of fasting for cancer patients. Conclusion: Diet and fasting play an important role of in targeted therapies for any cancer type, where tumor cells adapttheir metabolism to produce energy for growth and survival; fasting decreases circulating glucose,which is the preferential energy source of cancer, thus fasting could make therapies more effective by sensitizing cancer cells to protecting healthy cells from treatment toxicity, through decreasing circulating insulin-like growth factor-1, which limiting tumor development pathways.

Intermittent fasting, canser, immum diseases.