Wound care and treatment is crucial in hastening prompt recovery and healing of damaged skin or tissues. A wound healing effect was studied in vivo by clinical and histological evaluation in laboratory mice treated with guava leaf extract, povidone iodine solution and normal saline substances. Eighteen BALB/c mice were randomly divided into three treatment groups with six animals per treatment. Each animal served as replicate. Group I was treated with pure guava leaf extract, group II with povidone iodine, and group III, the control group, received plain normal saline solution. Each mice received daily applications of the medications tested. Animals were sacrificed and euthanized after 9 days. Tissue section stained with eosin and hematoxylin were examined and analyzed. Parameters on inflammatory cells, neovascularization, fibroblastic proliferation and epithelial regeneration and presence of red blood cells (RBCs) were evaluated through histological scoring system using the scale of 1-4. 1 for “none”, 2 (slight/few), 3 (moderate) and 4 (abundant). In vivo, histological data showed that neovascularization, fibrosis, and epithelialization were found to be substantially increased, an indication of a progressive healing following administration of guava leaf extracts. Inflammation was negligible in all guava leaf extract treated animals but with decreased RBC count, an indication of wound healing process conceivably occurring. Although those on the povidone iodine group yielded an observably a good or fair number of neovascularization, fibrosis and epithelialization and presence of RBCs, inflammatory cells are still high, an indication of prolonged healing process. Histologic data on guava leaf extract provided a higher range of healing efficacy with that of the commercial povidone iodine product. Overall findings suggest the effectiveness of P. guava leaf extract as compared to povidone iodine and superior in accelerated wound healing. With this, the “community” at the heart of this study has the premise of choosing better alternative low-cost medicines with equal potency with those synthetic preparations available in the market

guava, wound healing, antiseptic, healing rate, low-cost medicine.