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Volume 20 No 5 (2022)
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Effects of SaraswataChurna on spontaneous recurrent motor seizure activity in pilocarpine-induced epilepsy of rat model
Pugazhandhi Bakthavatchalam, Rajesh Thangarajan,R Huban Thomas, Venu Madhav Nelluri , Sudarshan Surendran
Abstract
The administration of pilocarpine to rats’cause’s status epilepticus (SE) and, after an incubation time, impulsive seizure. This model is frequently used to study epileptogenesismechanisms and novel compound antiepileptic properties.The goal of this study is to determine the amount of time it takes from SE to the first spontaneous seizures, as well as the type and frequency of spontaneous seizures in the early stages of pilocarpineinduced epilepsy, and also to evaluate the effect of SarswataChurna in the spontaneous recurrent motor seizure (SRMS) activity in the pilocarpine-induced rat model of epilepsy
Keywords
Epilepsy, Spontaneous Recurrent Motor Seizure, SaraswataChurna, Pilocarpine, Ayurvedic traditional herbs
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