Introduction:Sublingual immunotherapy (SLIT) has been considered to have more advantages than Subcutaneous immunotherapy (SCIT) in treating allergic rhinitis. Allergic rhinitis caused by cotton dust were concerned in Viet Nam. The study aimed to evaluate the effectiveness of SLIT in patients with allergic rhinitis caused by cotton dust. Materials and methods:The study is a cross-sectional study to review 52 patients with cotton dust induced allergic rhinitis who were treated with standard cotton dust allergen in 3 years. The functional symptoms, physical symptoms, prick test were compared before and after treatment, and adverse effects were recorded. Results:After 3 years of treatment with SLIT, all patients (100%) showed no or mild level of sneezing, runny nose, and nasal congestion. Most of thepatients (98.1%) did not have nose itching. Normal mucosa of nasal cavity and inferior turbinate by nasal endoscopewas 73.1% and 78.85% respectively. The concentration of serum IgE decrease significantly.The skin prick test was negative, accounted for 63.5%. There was no record of severe or life-threatening side effects. Conclusion:SLIT is effective with low adverse effects.

SLIT, allergic rhinitis, cotton dust