Aim: The aim of the present study is to estimate and compare the salivary levels of alkaline phosphatase and total protein in generalized chronic periodontitis subjects with or without uncontrolled type II diabetes. Materials and Methods: 60 subjects were included in this study. After the consideration of inclusion and exclusion criteria, subjects were divided into 2 groups, group I subjects had uncontrolled diabetes mellitus with generalized chronic periodontitis (DM+CP) and group II generalized chronic periodontitis subjects (CP). Clinical parameters i.e. plaque index, gingival index, and clinical attachment level & salivary ALP and total protein levels were also estimated using a fully automated analyser. Results: The present study showed a higher mean salivary ALP and total protein levels among the patients with type II diabetes mellitus (Group I) than non-diabetic individuals (group II). Conclusion: Salivary ALP and total protein levels reflects the inflammation and destruction of periodontal tissues, suggesting a useful marker in diagnosis of ongoing periodontal destruction.

chronic periodontitis; salivary biomarkers; Diabetes mellitus