The present work is to evaluated antioxidant and antihyperlipidemic activity of Corchorus trilocularis and Vitex trifolia in rat.Screening of antihyperlipidemic was done by using Corchorus trilocularis and Vitex trifolialeaves part extracts (200mg/kg and 400mg/kg). Hyperlipidemia was administered in experimental animals using triton X-100 administered intraperitoneally at a dose of (100 mg/kg). In order to collect blood for triton-induced hemolysis, heart punctures were performed after 7 dayshyperlipidemia. Antihyperlipidemic activity of Corchorus trilocularis and Vitex trifolia plant extracts were evaluated by estimation of lipid profiles and standard drug Atorvastatin for 7 days. The biochemical parameters such as the levels of total cholesterol, triglycerides, very lowdensity lipoprotein (VLDL), high density lipoprotein (HDL), and low density lipoprotein (LDL) are assessed. Estimation of lipid profile shows that Corchorus trilocularis and Vitex trifolia leaves extract (200mg/kg and 400mg/kg) shows the less significant antihyperlipidemic activity. It decreases TC, TG, LDL, VLDL and increases HDL levels. Corchorus trilocularis and Vitex trifolia leaves extract 200mg/kg and 400mg/kg shows significant antihyperlipidemic activity as standard drug Atorvastatin.This finding tends to reveal that the hyperlipidemic effects ofCorchorus trilocularis and Vitex trifolia (200mg/kg and 400mg/kg)are similar to the effect of standard drug Atorvastatin. This plant can get in consideration for the searching new drug to treat hyperlipidemic from plant

Corchorus trilocularis, Vitex trifolia, Triton x-100, Atorvastatin, Hyperlipidemia