Amebiasis is the third most common parasite-related cause of death globally caused by the protozoan Entamoeba histolytica The presence of parasites during pregnancy has been linked to hazards for pregnancy and undesirable outcomes. Little is known about their impact on the progression of pregnancies, This study aim reveal the influence of amebiasis incidence content on pregnancy before and after treatment with allicin. Female rats were divided into five groups of eight rats each, group (1) was given distilled water as a control, while groups 2, 3, 4, and 5 were infected with suspension E. histolytica. Every rat delivers cysts per mililiter via oral administration to patients at the Bint AL-Huda teaching hospital in Thi-Qar province of southern Iraq. and the group (3) was treated orally with metronidazole (20) mg/kg. group (4) gives allicin after infection at a rate of 0.3 mg/kg. group (5) gives allicin and metronidazole after infection. rats were placed for mating, and after confirming pregnancy and determining the first day of pregnancy, they were killed by ether and explained in the last trimester of pregnancy for gross and histological examinations. The results showed that group 2 had a significant reduction in uterine and ovarian weights (P≤ 0.01) when compared to groups g1, g3, g4, and g5. Histological findings revealed no pathological lesions in the genitalia of all the rats. There were significant differences between groups in When hormone levels were measured (P≤ 0.01) there was an improvement in female reproductive abilities by increasing the birth rate in groups 1, 3, and 4 compared to group 2. These results indicate that allicin improved the reproductive capabilities of female rats

Amebiasis, Allicin, Pregnancy, Natural Compound, Histopathology