Epilepsy is becoming one of the most frequent health issues in India, about 10 million people are suffering from epileptic seizures that affect their quality of life via several psychosocial complications. Hence, there is a reasonable requirement for the treatment of epilepsy. Epilepsy is defined as a chronic brain disorder indicated by periodic or unpredictable convulsion that have been classified into partial and generalized as well as simple and complex seizures. Several investigations suggest that epileptic seizures damage neurons in the hippocampus region which is one of the key factors in the rehabilitation of the loop during recurrent convulsions. The c-Jun N-terminal kinase (JNK), is a component of mitogen-activated protein kinases that participates in a variety of biological processes including apoptosis and inflammation. There has been a hypothesis that JNK hyperactivation may contribute to the pathophysiology of epilepsy. In-silico Molecular docking studies have been performed using Autodock 4.2 with the following receptors MAPK, Caspase 3 Receptor, Acetylcholinesterase, and Histone deacetylase.

Anti convulsant, Pentylene tetrazole, zebrafish, MAPK