Background An increase in body temperature that is more than the typical daily range because of a rise in the hypothalamic set point is referred to as a fever (e.g., Thirty seven to thirty nine degrees Celsius). It's a crucial sign that indicates a higher-than-normal internal body temperature. It is believed to be one of the body's immunological defence mechanisms against an inside threat. Febrile thrombocytopenia is thrombocytopenia associated with fever. Aim To analyse clinico-etiological profile in children having febrile thrombocytopenia. Methods The present retrospective study was conducted from 2nd March 2022 to 31st August 2023 in Sri Chamundeshwari medical College Hospital and Research Institute, Channapatna, Ramanagara, in the department of Pediatrics on 600 patients, age groupbetween 2months to 15 years of age presenting with fever. Date of onset of symptoms (fever, rash bleeding, joint swelling etc.), number of days for which symptoms continued, any history of blood disorder and any previous history of blood transfusion was asked. Details of specific diagnosis such as enteric fever, septicaemia and dengue were noted along with the treatment given. Entire clinical course till final outcome was studied and relevant details were noted. Results The vital cause for febrile thrombocytopenia were Dengue (32.83%) followed by malaria (18%). Bleeding manifestation was present in 123 (20.5%) subjects. Bleeding manifestations were recorded maximum among subjects suffering from dengue (47.20%) while it was found least in subjects with Disseminated TB followed by typhoid. When bleeding manifestations was compared according to etiology, it was found to be statistically significant. Platelet transfusion was needed in 67 subjects, out of which 19 (7.64%) required SDP (Single Donor Platelet) and 48 (28.36%) needed RDM (Random Donor Platelet). Conclusion thrombocytopenia is a common problem encountered in clinical practice. Knowledge of common causes of thrombocytopenia and their clinical manifestations will help in deciphering the cause of thrombocytopenia and formulating diagnostic and therapeutic strategy. Rapid diagnostic tests for malaria and dengue are helpful in ruling out these diseases.

thrombocytopenia, Febrile, Platelet, Dengue