Evaluation of Polymorphisms in miRNAs; miR-196a2 and miR-146a and Type 1 Diabetes Mellitus Children

Volume 20 No 5 (2022)

Yaser Mukhtar Alati , Hanaa Abdulfatah Mostafa , Ashgan Abdalla Alghobashy , and Heba Fouad Pasha

DOI: 10.14704/nq.2022.20.5.NQ22652

Abstract

Background: Type 1 diabetes mellitus (T1DM) results from a cellular mediated autoimmune destruction of pancreatic β-cells, leaving patients insulin-dependent for life . The triggering of autoimmunity against β-cells arises from a multifaceted interaction between multiple genetic and environmental risk factors. More than 50 genes have been identified to influence the risk of T1DM, with HLA class II genes having the greatest impact on susceptibility

Keywords

Type 1 Diabetes Mellitus, Genes, miR-196a2 and miR-146a

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