Osteoarthritis causes degenerative changes in the joints i.e. “wear and tear” resulting in pain and impaired function.Pathological cartilage loss occurs due to imbalance in the catabolic& anabolic mechanisms of cartilage remodeling.Ethanolic extract of Cissusquadrangularis andNigella sativa in different combination was prepared such as Cissus quadrangularis and Nigella sativa (50:50, 20:80 and 80:20).Anti-inflammatory evaluation of extract was done by using carrageenan induced paw edema model ; analgesic activity evaluation of extract was done by using acetic acid-induced writhing test andosteoarthritis evaluation of extract was done activity by using collagenase type II-induced osteoarthritis (CIOA) rat model was carried out.Though the combination ethanolic extract Cissus quadrangularis and Nigella sativa (20:80)shows better anti-inflammatory and analgesic activity; ethanolic extract of Cissus quadrangularis and Nigella sativa (80:20) was found to be more efficient in treating osteoarthritis

Osteoarthritis, Cissusquadrangularis and Nigella sativa