Ameloblastoma and odontogenic keratocyst are the major odontogenic neoplastic lesions. Ameloblastoma and odontogenic keratocyst are high reccurence. Treatment for ameloblastoma and odontogenic keratocyst is classified as conservative or radical approach. The purpose of the research to evaluate the surgical approach in treatment of ameloblastoma with odontogenic keratocyst and recurrence rate. A 36 years old woman with nasal obstruction in her right side for a year, blood stain rhinorea and facial swelling. Computerized tomography showed a isodens mass, non calsification, well defined margin, extending from nasal cavity to nasopharynx, bilateral maxillary sinus, zygoma area and bilateral buccal region. The mass was destructed nasal bone, bilateral zygomatic bone, bilateral alveolar maxillary bone and the wall of bilateral maxillary sinus. Pre-operative histological examination showed ameloblastoma with keratinizing odontogenic cyst (odontogenic keratocyst). Total maxillectomy with obturator was performed. Patient followed up for a year without recurrence. A PubMed database and ScienceDirect search were conducted. the search resulted in two useful articles were critically appraised. Result of the research that the risk of recurrence for ameloblastoma and odontogenic keratocyst following radical treatment was lower than conservative treatment. Radical approach can be a good choice for ameloblastoma with odontogenic keratocyst for prevent the recurrence. The patient should followed up regularly to observe recurrence.

Ameloblastoma, Odontogenic Keratocyst, Radical Approach, Conservative Approach, Maxillectomy, Recurrence