Colon targeted drug delivery systems have drawn a lot of interest as possible means of delivering different therapeutics that are susceptible to enzymatic and acidic degradation in the upper gastrointestinal tract, as well as for the local treatment of colonic diseases with fewer systemic side effects. Growing patient demands for a more patient-friendly drug administration system and the expansion of the global pharmaceutical market for biologics in recent years underscore the significance of colonic drug delivery as a noninvasive method of delivering macromolecules. Because they are painless and self-administerable, colon-targeted drug delivery devices for macromolecules can offer therapeutic advantages such as increased patient compliance and reduced costs. Therefore, a number of approaches, such as pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems, have been investigated in order to obtain more effective colonic drug delivery for local or systemic therapeutic effects. Recent developments in several methods for creating colon-targeted drug delivery systems and their medicinal uses are reviewed in this study, with a focus on formulation technology.

colon, inflammatory bowel conditions, noninvasive medication administration, colorectal cancer, and protein medicines