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Volume 20 No 22 (2022)
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FORMULATION AND DEVELOPMENT OF SOLID DISPERSION OF INDOMETHACIN DRUG USING MIXED SOLVENCY
Manohar Chouhan, Monika Kharb, Mohit Chaturvedi, Revathi A. Gupta
Abstract
The aim of research work formulation and in vitro evaluation of solid dispersion, ecofriendly solid dispersion techniques involve incorporating a poorly water-soluble drug into aa water-soluble carrier matrix to enhance its dissolution rate and bioavailability of drug” Mixed solvency concept can solve the problem of toxicity of organic solvent in use a pharmaceutical formulation. Wecan avoid the use of a high concentration of a single solubilizer use in different Formulation like Solid dispersion , Solubility Enhancement method of poorly water soluble drug Mixed solvency concept use for formulation dispersion in use for types of water soluble carrier like PVP-K30, Sodium benzoate, PEG6000 and sodium citrate and different ratio 1:1,1:2,1:3,1:4,1:5,1:6,1:7,and 1:8 and code of preparation SDMSIM-1,SDMSIM-2, SDMSIM-3,SDMSIM-4,SDMSIM-5, SDMSIM-6 SDMSIM-7 and SDMSIM-8 formulation of solid dispersion and examined evaluation parameter of solid dispersion all preparation and It found preparation code SDMSIM- 5 best Result min concentration show so it can use for formulation other dosage form preparation.
Keywords
Solid dispersion, Mixed solvency, Solubility Enhancement Method, Poorly Water-Soluble drug.
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