The study evaluated two novel coprocessed excipients (with three methods) as disintegrants in a fastdissolving domperidone tablet formulation. The tablets produced were assessed for mechanical properties with the use of friability and tensile strength while the release properties were assessed with wetting time, water absorption ratio, disintegration time and dissolution profile. The results obtained showed that the methods of coprocessing and disintegrant incorporation influenced the activities of the disintegrants. The novel disintegrant enhanced the mechanical properties of the tablets containing them as shown by lower friability and higher tensile strength of the tablets. The result further showed that the rate and amount of water absorbed, type of disintegrant and the method of disintegrant incorporation influenced the total amount of domperidone released. The study concluded that the novel disintegrants will be effective in the formulation of fast dissolving domperidone tablets

coprocessing, lyophilization, microwave, solvent evaporation, dissolution, friability, disintegration time, water absorption ratio, wetting time