Chronopharmceutics is the branch of pharmaceutics that develops the formulation that will release the bioactive agent at the rhythm that identically matches the biological requirement of a given disease therapy in real time. Atorvastatin is a member of the drug class known as statins. It is used for lowering cholesterol. It inhibits the rate determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives. The maximum release ( cholesterol synthesis will occurred at night as compared to day) when we administered conventional dosage form of Atorvastatin , 40% of drug released before the requirement of the biological system , so to avoid the release of drug before requirement, we are formulating chronomodulated drug delivery system of Atorvastatin. Drug was entrapped in calcium alginate beads and further coated with release controlling polymer and filled in hard gelatin capsule shell. From the dissolution studies it was observed that enteric coating of CAP was intact for 2hr. in pΗ 1.2 buffer. On the basis of in-vitro release studies and other evaluation parameters formulation F2,F3 and F6 were selected as optimized formulation for designing pulsatile device

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