In the current study, several grades of HPMC and ethyl cellulose were used as the retarding polymers to create controlled release tablets of quetiapine fumarate. All the formulations were created utilizing the direct compression method on an eight-station rotary tablet punching machine with a 12mm punch. All the formulations combined demonstrated good flow characteristics in terms of angle of repose, bulk density, and tapped density. The created tablets had good post-compression properties, and they met all the I.P.-required quality control evaluation criteria. F2 is regarded as an optimal formulation because it had the highest percentage of drug release of all the formulations (97.3 percent in 8 hours). As the polymer content increased, the formulations incorporating HPMC K100M displayed greater retardation. Guar gum compositions failed to generate the desired rug release pattern

Quetiapine fumarate, HPMC K15M, HPMC K100 M, Guar gum, Controlledrelease tablets