The aim of this study was to develop transdermal patch of Eberconazole Nitrate which has good mechanical properties. Transdermal drug delivery is a medicated patch that delivers a specific amount of medication through the skin into the blood stream. An advantage of a transdermal drug delivery route over other types of medication delivery is that the patch provides a controlled release of the medication into the patient, either through a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Drug-loaded matrix- types Transdermal Patch of Eberonazole Nitrate were prepared by using solvent casting method. Transdermal patches evaluated for physicochemical parameters like thickness, weight variation, moisture uptake, moisture content, Water Vapor Transmission Rate, drug content values & In-vitro release study by Franz diffusion Cell method. Seven transdermal patches were prepared using different concentrations of Hydroxy Propyl Methyl Cellulose (HPMC). It was concluded that as the concentration of polymer increases the thickness of patch, weight uniformity increases. Percentage moisture content and percentage moisture uptake decreases with increase in polymer concentration

Eberconazole Nitrate, Transdermal Patch, Water Vapor Transmission Rate, Franz diffusion Cell method,.