Allicin is a potent bioactive compound derived from Garlic, with diverse biological properties and potential health benefits. The biological properties of allicin, such as its antimicrobial effects against bacteria and fungi, as well as its antioxidant capabilities in scavenging reactive oxygen species, underscore its potential in promoting human health. As scientific understanding deepens and research progresses, allicin may become an essential component in the development of novel therapeutics and preventive measures, offering a natural and versatile solution to various health challenges. From ancient topical cream formulations to novel topical drug delivery methods, the pharmaceutical industry has undergone a revolutionary transformation. In the present paper Allicin loaded niosomes were formulated by using thin film hydration technique and the different nonionic surfactants (span 20, span 60, tween 40 & tween 60) grades in different drug:surfactant: Cholesterol ratios as 1:1:1, 1:2:1, 1:1:2 and was further evaluated.

Allicin, Niosomes, Formulation