The major objectives of this research were the creation and assessment of an aloe vera-based ointment. In this investigation, a number of drugs were combined in order to create these combinations. When evaluating the base's pH, strength, spread-ability, water number, and wash ability against the standard base, it was put to the test against the standard base. It was also examined for compatibility, drug content, in vitro drug diffusion and ex vivo permeability, as well as skin irritation on rats' skin, for the development and improvement of the enhanced formulation. In addition, all of the ointment formulations were determined to have acceptable physicochemical qualities. Prototype formulations based on the USP criteria were not as effective as formulation F5, which included greater doses of aloevera and metronidazole. Based on its viscosity, strength, and spreadability, Formulation F5 was chosen as the best formulation. Metronidazole was shown to have acceptable medicinal properties for ointment formulation. It's possible that it'll displace more costly ointment bases in the near future.

Metronidazole, Aloe Vera, Skin disorders