Ketoconazole is an antifungal medication used to treat a variety of fungal infections. It belongs to a class of medications known as azole antifungals and works by preventing fungi from producing ergosterol, which is an important component of fungal cell membranes. In this study, a novel invasomal gel containing ketoconazole was developed as a topical delivery system for the treatment of fungal skin infections. Ketoconazole -loaded invasomal gels were prepared using various concentrations of carbopol. The formulation was characterized for pH, viscosity, Gel strength, Drug content, Extrudability study, Spreadability, In vitro drug diffusion study and Stability studies.The invasomal gel also showed good skin permeation characteristics in Franz diffusion cells. In addition, the invasomal gel was found to be safe and non-irritating when tested in a rabbit skin irritation test. The results of this study demonstrate that the Ketoconazole -loaded invasomal gel is a promising topical delivery system for the treatment of fungal skin infections.

Ketoconazole,Invasomal Gel, Formulation, Characterization