Curcumin has been the focus of several researches, all of which indicate that it has tremendous therapeutic potential. Curcumin's ability to heal cancer has long been the focus of intense investigation. Using the solvent casting approach, transdermal patches containing curcumin-loaded solid lipid nanoparticles were created using PEG-400 as a plasticizer and HPMC and PVP-K30 as polymeric matrix materials. The patches are stable and show no interaction between the medicine and the formulation components. The average weight of the patches was determined to be between 147 and 163 mg. The thickness of the patches ranged from 0.261 to 0.312 mm and was shown to be depending on the concentration of PVP-K30. The folding endurance test findings demonstrated that the thinner patches were more flexible, withstanding 67 to 94 folds at the same location without obvious cracking or breaking. All formulations were able to integrate a significant quantity of medication, ranging from 98.16 to 99.22 percent. The moisture content analysis found that increasing the concentration of PVPK30 had an inverse effect on the moisture content in the patches, with SLNP-4 having the lowest moisture (6.03 percent) and SLNP-1 having the greatest (6.51 percent). The medication was released in several formulations at rates ranging from 67.3 to 59.7 percent. The regression coefficients of the mathematical models' graphical depiction show that the release of curcumin from the patches may be represented by the Korsemeyer-Peppas model. It expresses that the drug released from patches is due to drug diffusion from the patch matrix and is mostly diffusion regulated.

Curcumin, Transdermal patches, Solid lipid nanoparticles, In vitro, Zeta-potential