Formulation and Evaluation of the Floating Controlled Release Tablet of Fosinopril sodium by using a hydrophilic polymer matrix

Volume 19 No 11 (2021)

Jalpa R. Patel, Mahavir Chhajed , Darpini S. Patel , Bhavik A. Patel , Santosh Kumar Vaidya , Manmeet Singh Saluja

DOI: 10.14704/nq.2021.19.11.NQ21242

Abstract

Objectives: The purpose of the study was to develop a floating Controlled tablet of Fosinopril sodium by using a hydrophilic polymer matrix to improve the therapeutic effectiveness of the drug. Methods: Fosinopril sodium tablets were prepared by direct compression and evaluated for FTIR of Pure Drug, drugexcipients compatibility, Pre and Post Evaluation Studies, in-vitro Studies study, Stability Study.. Results: DSC and FT-IR studies confirmed the absence of incompatibility and were found stable at refrigerator temperature (2-8°C) and at 25ºC/60% RH

Keywords

Floating, erodible diffusion, prodrug, Sterculia Foetida Gum

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