The aim of the study was to formulate and characterize herbal nanoemulgel of Nyctanthes arbor-tristis and Aloe Vera. Nanoemulgel was formulated using three different gelling agents including Carbapol 934, Carbapol 940 and HPMC. The characterization studies were performed for physical appearance, pH, viscosity, drug content analysis, in vitro skin permeation studies and in vitro anti-inflammatory activity by IL-6 inhibition. Results showed that all the Nanoemulgel were found to be stable formulations with pH ranging from 6.17–6.43. Viscosity measurement revealed that all formulations were having Newtonian flow behavior with varying viscosities depending upon their composition. In vitro drug release study pronounced the maximum release with the more than 95%. The particle size analysis showed that all the formulations were within the nanometer range between 100.22±0.16 to 102.20±0.10 nm, indicating successful formation of nanoemulgel. A negative zeta potential indicated that the particles repel each other, which is necessary for stable dispersions; the zeta potential was found 24.60±0.44 to 37.40±0.44. In vitro anti-inflammatory studies results revealed that the formulated Nanoemulgel could potentially inhibit the IL-6 by 76%.

Nanoemulgel, Herbal Nanoemulgel, Nyctanthes arbor-tristis and Aloe Vera Nanoemulgel