Volume 21 No 2 (2023)
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Formulation of tolnaftate emulgel for topical delivery
Chakresh Patley , Kaminee Sahu , Kavita Shukla , Imran Mansoori , Reetesh Chourasia , Rahul Nayak
Nanoemulsion gelling system is an ideal drug delivery system for most of the drugs with objective of maximizing efficacy while minimizing toxicity. Nanoemulsion system comprises the mixture of nanoranges of two immiscible liquids (water and oil) to form a homogeneous system by adding suitable surfactant/co-surfactants with appropriate HLB value. This thermodynamically stable system ranges from 10-100 nm. The study include topical nanoemulgel will formulate by adding natural oils, gelling agents, stabilized surfactants with addition of co-surfactants, in aqueous phase to the optimized characteristics both of nano emulsions and gels and maintaining of skin pH. Current study is to expand nano emulgel of tolnaftate as anti-fungal drug. The drug delivery system provides better-permeable delivery of effective moeighty via topical route in controlled and localized manner.
Nano-Emulsion, Drug delivery system, Nano-emulgel.
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