INTRODUCTION Malaria is a protozoan disease caused by infection with parasites of the genus plasmodium and transmitted to man by certain species of infected female Anopheles mosquito. A typical attack comprises three distinct stages: cold stage, hot stage and sweating stage. 1 The clinical features of malaria vary from mild to severe, and complicated, according to the species of parasite present, the patient's state of immunity, intensity of the infection and also the presence of concomitant conditions such as malnutrition or other disease. 2 The febrile paroxysms occur with definite intermittent periodicity repeating every third day or fourth day depending upon the species.3 MATERIALS AND METHODS A cross sectional study was conducted in the General Medicine department from July 2023 to January 2024. A total of 50 patients diagnosed with severe falciparum malaria as per WHO criteria 2022 who were admitted in general medicine ward. All cases of Plasmodium falciparum malaria diagnosed by peripheral smear examination or by immunochromatographic test- Falci Check or by Rapid diagnostic test were included in the study. All cases (50) of plasmodium falciparum malaria diagnosed were included in the study and conducted following tests for every patient along with detailed history and physical examination. RESULTS On comparison of gender with Glasgow coma scale as depicts that only 3 number of male patients are having glasgow come scale is 3-6 which implies poor prognosis and 4 number of female patients are having Glasgow coma scale is 3-6 which implies bad prognosis and it is statistically insignificant(p=0.228). On comparison of gender with serum creatinine levels as depicts only 7 number of male patients are having serum creatinine levels>3mg/dL which implies poor prognosis and remaining 21 numbers of male patients are having serum creatinine levels <=3 mg/dL which implies good prognosis. And compared to male patients only 6 number of female patient are having serum creatinine levels >3mg/dL which implies poor prognosis and it is statistically insignificant(p=0.760). On comparison of gender with serum bilirubin levels(mg/dL) as depicts only 3 number of male and female patients are having serum bilirubin levels >10mg/dL which illustrate that poor prognosis and it is statistically insignificant(p=0.687). Total score is 10. and those patients with GCRBS < 7 cutoff score is considered as good prognosis, and >/= 7 considered as bad prognosis in the present study. CONCLUSION In present study out of 50 patients with severe falciparum malaria, 88 patients have GCRBS cutoff score <7, of which 13 ( 14.8% ) patients were with multi organ failure , and 75 (85.2%) patients were without multi organ failure. 12 patients have GCRBS cutoff score >7,of which 6 (50%)patients were with multi organ failure, and 6 (50%) patients were without multi organ failure.

Malaria, GCS, Creatinine, Respiratory rate, Bilirubin and Systolic BP (GCRBS).