Depression become the most health problem especially after COVID-19 pandemic in Iraq by increased the psychiatric disorder, the present study focused on the Mitochondrial Genes (ND1, ATP6c) in Depression patients using PCR-SSCP technique, samples collection with patients data were collected from psychiatric clinic, then DNA isolation and genes polymorphisms were detected, the results show that patients recorded in age more than 40 years and in married than single individuals in significant differences, non- significant differences were observed in occupational status, the genotyping found tow haplotypes in ATP6c gene (A and B) in significant differences between for B haplotype frequent in patients, the ND1 polymorphisms show three haplotypes (A, B and C) that varied in non-significant differences between patients and control, the present results concluded association between ATP6c and depression disease but didn’t found linked with ND1 polymorphism

Depression, ND1, ATP6c, Haplotypes, PCR-SSCP