Green Analytical Chemistry (GAC) has emerged as a pivotal approach in the field of analytical chemistry, emphasizing the development of sustainable and environmentally friendly analytical methods. This review provides a comprehensive overview of the principles, applications, and future directions of GAC. The paper discusses the definition and scope of GAC, highlighting its importance and relevance in modern science. It also outlines the objectives of the review, which include examining successful implementations of GAC in various fields, comparing traditional and green analytical methods, and identifying challenges and limitations in the field.The review covers key principles of GAC, such as waste prevention, atom economy, and the use of renewable feed stocks. It also discusses green analytical methods and techniques, including the use of green solvents, miniaturization, and non-chromatographic techniques. Case studies and examples illustrate the successful implementation of GAC in environmental monitoring, pharmaceutical analysis, food safety, industrial applications, and clinical and biomedical analysis.

Green Analytical Chemistry, sustainability, environmental impact, green solvents, miniaturization, non-chromatographic techniques, environmental monitoring, pharmaceutical analysis, food safety, industrial applications, clinical analysis, green technologies, policy and regulation.