Our study showed the therapeutic effect of Gum Arabic(15%) on male rats after being injected with carboplatin(50mg/kg), Which is used to treat cancer and has serious side effects on cancer patients, including hepatotoxicity and oxidative stress. Our results showed the group was injected with carboplatin abnormalities in liver function and an increase in the percentage of liver enzymes such as the alanine aminotransferase, the aspartate aminotransferase, Alkaline phosphatase, and Gammaglutamyl transferase in the blood, in addition to a decrease in antioxidants such as Catalase and Glutathione and an increase in the Lipid peroxide in the liver tissue. As for the group treated with Gum Arabic after being injected with carboplatin, there were few statistically significant differences when compared with the control group; the Gum Arabic reduced the hepatotoxicity induced by carboplatin and the level of liver enzymes in the blood to The normal level, as well as lipid peroxidation, increased the percentage of antioxidants in the tissues. The reason is due to the properties of Gum Arabic, as it is considered a free radical scavenger, antioxidant, and anti-inflammatory, and is used as a treatment in alternative medicine.Our study aims to reduce the hepatotoxicity induced by carboplatin in male rats using herbal medicine (Gum Arabic). It preserved the liver from oxidative stress and protected the liver from damage.

Acacia senega,Cancer, Herbal medications,liver toxicity, platinum drug, oxidative stress