Hemidesmus indicus is also known as Indian sarsaparilla. It also called as endless root. Hemidesmus indicus is known to have many therapeutic benefits. The present investigation aimed in determining effectiveness of ethanolic extract of Hemidesmus indicus leaves as an analgesic and antiinflammatory agent. The leaves of Hemidesmusindicus were collected and dried. The extraction was carried out through maceration process. The rats weighing around 150-200g and mice weighing 25- 30g were selected. Acute toxicity study exhibited ethanolic extract of Hemidesmus indicus leaves is safe up to 2000mg/kg. The ethanolic extract of Hemidesmus indicus leaves were used in the corresponding doses - 100, 200, 400 mg/kg body weight. Analgesic activity was evaluated based on “Tail immersion Method” and “Acetic acid induced writhing method”. The central and peripheral analgesic effect was evaluated. The anti-inflammatroy activity was evaluated based on carrageenan induced rat paw oedema method and in-vitro method like inhibition of albumin denaturation. In both the activities test dose of 200mg, 400mg/kg body weight of extract showed significant activity. Preliminary photochemical analysis of ethanolic extract of Hemidesmus indicus leaves revealed the presence of constituents like tannins, saponins, flavanoids, and glycosides. According to these findings the ethanolic extract of Hemidesmus indicus possesses a significant analgesic and antiinflammatory activity.

Hemidesmus indicus, tannins, Analgesic activity, anti-inflammatory activity, Acetic acid, carrageenan