Hyaluronic acid (HA) or hyaluronan is a linear nonsulphated glycosaminoglycan found commonly in the vertebrate extracellular matrix (ECM).It forms a strikingly viscoelastic matrix, which in part serves as a medium for connective tissue cells and it has been implicated in chondrogenesis and cartilage homeostasis, embryonic development, immunomodulation, wound healing, and a variety of disease processes, including arthritis, malignancies, and pulmonary and vascular disease, together with other immune and inflammatory disorders.Hyaluronic acid in specific is now used in the form of gel injections which were injected in the dermis of the penile skin just above the nerve terminals, allowing to achieve a volume sufficient to prevent Premature ejaculation and reduce the intensity of stimuli reaching sensory receptor's. Study evaluated the effect of hyaluronic acid in 60 men affected by PE, demonstrating that (IELT) increased 1 month after the injection of the compound in their penis. Multiple studies showed that HA injection could significantly increase the intra-vaginal latency time (IELT) (2.43- to 4.46-fold), and this increase could persist for long term (up to 5 years)

Hyaluronic Acid, Premature Ejaculation