Odontogenic tumors are lesions arising from odontogenic apparatus, their remnants or their derivatives that present as a combination of established lesions which have been referred by researchers as “hybrid” or “combined” lesions. The components of hybrid odontogenic tumors are often histologically identical to other odontogenic tumors such as odontogenic keratocyst (OKC), glandular odontogenic cyst (GOC), ameloblastoma and adenomatoid odontogenic tumour (AOT). Their clinical presentation ranges from non-invasive cysts or hamartomas to benign and malignant neoplasms that vary greatly in their tendency for expansion and aggression. Nevertheless, such tumours have been reported in the literature for academic and research interest. However, it is still obscure whether they behave as a new entity or they solely present separate histopathologic patterns. Here, we present a rare case report of true hybrid tumour of combined odontogenic keratocyst with ameloblastoma with intermixed histopathologic patterns of both the cyst and tumour.

Hybrid tumours, odontogenic keratocyst, ameloblastoma