MAGL is an important key enzyme responsible for various factors in the human body and the development of disorders like pain, inflammation, CNS disorders and cancer. MAGL has an important function in the endocannabinoid system and is responsible for of hydrolysis one of the endocannabinoids, 2-arachidononoylglycerol lipase. 2-arachidonoylglycerol lipase has an agonist action for G-protein coupled receptors CB1 and CB2. MAGL also causes the incline in the concentration of specific lipids like lysophosphatidic acid, phosphatidic acid, prostaglandin E2 and sphingosine-1-phosphate derived from free fatty acids which play important role in the proliferation of cells, survival, migration, metastases, and development. In the current work, we are presenting the docking-based screening studies of various designed MAGL inhibitors by studying the different essential features of previously developed different potent inhibitors of enzyme monoacylglycerol lipase

Inflammation; Cancer; Inhibitors; Lipase; Enzyme; Anticancer; Arachidonic acid; Monoacylglycerol Lipase.